From the Long Island Expressway:
Exit 70 South on Route 111 - toward Eastport- for 2 miles to Eastport-Manor Road - exit to the right Continue 1/2 mile to the Shrine entrance on the right.
From Sunrise Highway - Route 27 - eastbound
Exit 61 - from the exit ramp take the exit for Eastport. Go left at the light on Eastport Manor Rd. (toward Manorville. Go through the light (County Rd. 51) and continue on Eastport Manor Rd 2 miles to Shrine entrance on the left.
From Sunrise Highway - Route 27 - westbound
Exit 62 - Route 111 - Manorville. Take service road to 2nd light - go right onto Eastport Manor Road for about 2 miles. The Shrine entrance is on your left.