From the Long Island Expressway:

Exit 70 South on Route 111 - toward Eastport- for 2 miles to Eastport-Manor Road - exit to the right Continue 1/2 mile to the Shrine entrance on the right.

From Sunrise Highway - Route 27 - eastbound

Exit 61 - from the exit ramp take the exit for Eastport. Go left at the light on Eastport Manor Rd. (toward Manorville. Go through the light (County Rd. 51) and continue on Eastport Manor Rd  2 miles to Shrine entrance on the left.

From Sunrise Highway - Route 27 - westbound

Exit 62 - Route 111 - Manorville. At the light, go right (north-bound) on Rt. 111 for 1.5 miles. Move to the left lane - watch for Eastport Manor Rd. exit on left. Cross Rt. 111 (the south-bound lanes), at next intersection (Eastport Manor Rd). Go right 1/3 mile to  Shrine entrance on the left